Polycomb segment myeloid malignancies.
نویسندگان
چکیده
An unexpected revelation of cancer genome studies has been frequent abnormality in genes for factors that modify chromatin, underscored in this issue of Blood by reports from Score et al and Kroeze et al of inactivating mutations and chromosome loss in SUZ12, EED and JARID2 in myelodysplastic syndrome (MDS) and myeloproliferative disease (MPD).
منابع مشابه
Impaired maturation of myeloid progenitors in mice lacking novel Polycomb group protein MBT-1.
Polycomb group (PcG) proteins participate in DNA-binding complexes with gene-repressing activity, many of which have been highlighted for their involvement in hematopoiesis. We have identified a putative PcG protein, termed MBT-1, that is associated with Rnf2, an in vivo interactor of PcG proteins. MBT-1 structurally resembles the H-L(3)MBT protein, whose deletion is predicted to be responsible...
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ورودعنوان ژورنال:
- Blood
دوره 119 5 شماره
صفحات -
تاریخ انتشار 2012